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Adverse events following immunization (AEFI) after yellow fever Vaccination.


  1. Mild Side Effects of Vaccination:-


  1. More Serious Side Effects of Vaccination :-

3. What if there is a severe reaction?

a. What should I look for?

Look for any unusual condition, such as a high fever, behavior changes, or flu-like symptoms

Signs of an allergic reaction can include difficulty in breathing, hoarseness or wheezing, hives, paleness, weakness, a fast heart-beat, or dizziness within a few minutes to a few hours after the vaccination.

b. What should I do?

Call a doctor, or get the person to a doctor right away. Tell the doctor what happened, the date and time it happened, and when the vaccination was given.

There have been rare reports of serious side-effects from the yellow fever vaccine. The rates for these severe ‘adverse events following immunization’ (AEFI), when the vaccine provokes an attack on the liver, the kidneys or on the nervous system, leading to hospitalization, are between 0.4 and 0.8  per 100 000 people vaccinated.


The risk is higher for people over 60 years of age and anyone with severe immunodeficiency due to symptomatic HIV/AIDS or other causes, or who have a thymus disorder. People over 60 years of age should be given the vaccine after a careful risk-benefit assessment.

People who are usually excluded from vaccination include:


In accordance with the International Health Regulations (IHR), countries have the right to require travelers to provide a certificate of yellow fever vaccination. If there are medical grounds for not getting vaccinated, this must be certified by the appropriate authorities.

IHR are a legally binding framework to stop the spread of infectious diseases and other health threats. Requiring the certificate of vaccination from travelers is at the discretion of each State Party, and it is not currently required by all countries.